Claudio Doglioni - To make an appointment - GSD

Biography

Professor Claudio Doglioni is the Head of the Department of Pathological Anatomy at IRCCS Ospedale San Raffaele in Milan, as well as the Ordinary Professor in Pathological Anatomy at the University of Vita-Salute San Raffaele.

After graduating from the Faculty of Medicine and Surgery in Ferrara, he specialized in pathological anatomy and laboratory techniques at the University of Parma. In 1986, he completed his second specialization in oncology at the University of Ferrara. He was a visiting fellow in the Pathology Department of University College London in 1991 and the Pathology Department of the University of Washington, Seattle in 1999.

In his diagnostic and research work, the Professor Doglioni specializes, in particular, in diseases of the pancreas, lungs and breasts, treating more than 4,000 patients every year. In addition, he has extensive experience in the immunohistochemical field. He became the first expert to find out how calretinin is a marker of mesothelioma, CDX2 protein is a marker of colon tumor, and p63 is a marker of myoepithelial cells in breast pathologies. His laboratory includes an immunohistochemistry section and a molecular diagnostics section. His special contribution to medicine was the demonstration of the effectiveness of antibiotic treatment for the eradication of Helicobacter pylori infection in the treatment of gastric lymphomas of the MALT type.

The main interest for him is the determination of diagnostic and prognostic molecular markers in oncology, identification of molecular changes in genes involved in the development of tumors, the study of the pathogenic role of infectious agents in MALT lymphoma (lymphoid tissue of the mucous membranes) and the use of various immunohistochemical methods.

He is the author of 420 articles (Impact Factor is 1.802,578, Hirsch index in Scopus database is 75) published in international journals such as The American Journal of Pathology, Genes & Development, Laboratory Investigation, Anticancer Research, Blood, Annals of Oncology, Clinical Cancer Research and Lancet. He is the member of the Editorial Board of the Advanced in Anatomic Patholofy and Pathologica journal, the member of the International Academy of Pathology, American Association for the Advancement of Science, Italian Society of Pathological Anatomy, and also the co-founder of the Italian Group for Immunohistochemistry (GYM).

Education

Ferrara University
Degree in Medicine and Surgery - 1978

University of Parma
Specialization in Pathological Anatomy and Laboratory Techniques - 1981

Ferrara University
Specialization in Oncology - 1986

Publications

The author of 420 articles (Impact Factor is 1.802,578, Hirsch index in Scopus database is 75) published in international journals such as The American Journal of Pathology, Genes & Development, Laboratory Investigation, Anticancer Research, Blood, Annals of Oncology, Clinical Cancer Research and Lancet.

Latest publications

Four-class tumor staging for early diagnosis and monitoring of murine pancreatic cancer using magnetic resonance and ultrasound.

CARCINOGENESIS, ISSN: 0143-3334, doi: 10.1093/carcin/bgy094

Dugnani, Erica, Pasquale, Valentina, Marra, Paolo, Liberati, Daniela, Canu, Tamara, Perani, Laura, De Sanctis, Francesco, Ugel, Stefano, Invernizzi, Francesca, Citro, Antonio, Venturini, Massimo, Doglioni, Claudio, Esposito, Antonio, Piemonti, Lorenzo (2018).

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 114, p. 10202-10207. (2017).

Cohen JD, Javed AA, Thoburn C., Wong F., Tie J., Gibbs P., Schmidt CM, Yip-Schneider MT, Allen PJ, Schattner M., Brand RE, Singhi AD, Petersen GM, Hong SM, Kim SC, Falconi M., Doglioni C., Weiss MJ, Ahuja N., He J., Makary MA, Maitra A., Hanash SM, Dal Molin M., Wang Y., Li L., Ptak J., Dobbyn L., Schaefer J., Silliman N., Popoli M., Goggins MG, Hruban RH, Wolfgang CL, Klein AP, Tomasetti C., Papa

How to prepare, handle, read, and improve EUS-FNA and fine-needle biopsy for solid pancreatic lesions: The pathologist's role.

ENDOSCOPIC ULTRASOUND, vol. 6, p. S95-S98. (2017).

Biermann K., Escario MDL, Hébert-Magee S., Rindi G., Doglioni C.

PD-L1 Expression and CD8 T-cell Infiltrate are Associated with Clinical Progression in Patients with Node-positive Prostate Cancer.

EUROPEAN UROLOGY FOCUS, ISSN: 2405-4569, doi: 10.1016/j.euf.2017.05.013. (2017).

Petitprez Florent, Fossati Nicola, Vano Yann, Freschi Massimo, Becht Etienne, Luciano Roberta, Calderaro Julien, Guedet Tiffany, Lacroix Laetitia, Rancoita Paola M.V., Montorsi Francesco, Fridman Wolf Herman, Sautes-Fridman Catherine, Briganti Alberto, Doglioni Claudio, Bellone Matteo.

PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes.

JCI INSIGHT, vol. 2, ISSN: 2379-3708, doi: 10.1172/jci.insight.87380. (2017).

Ponente M., Campanini L., Cuttano R., Piunti A., Delledonne GA, Coltella N., Valsecchi R., Villa A., Cavallaro U., Pattini L., Doglioni C., Bernardi R.

TFH-derived dopamine accelerates productive synapses in germinal centres.

NATURE, vol. 547, p. 318-323. (2017).

Papa, Ilenia, Saliba, David, Ponzoni, Maurilio, Bustamante, Sonia, Canete, Pablo F., Gonzalez-Figueroa, Paula, McNamara, Hayley A., Valvo, Salvatore, Grimbaldeston, Michele, Sweet, Rebecca A., Vohra, Harpreet, Cockburn, Ian A., Meyer-Hermann, Michael, Dustin, Michael L., Doglioni, Claudio, Vinuesa, Carola G.

Selecting patients for resection after primary chemotherapy for non-metastatic pancreatic adenocarcinoma.

ANNALS OF ONCOLOGY, vol. 28, p. 2786-2792, ISSN: 0923-7534, doi: 10.1093/annonc/mdx495 (2017).

Reni, M., Zanon S., Balzano G., Nobile S., Pircher CC, Chiaravalli M., Passoni P., Arcidiacono PG, Nicoletti R., Crippa SS, Slim N., Doglioni C., Falconi M., Gianni L.

Gastroenteric neuroendocrine neoplasms classification: comparison of prognostic models.

CANCER, vol. 119, p. 36-44, ISSN: 0008-543X, doi: 10.1002/cncr.27716 (2013).

Dolcetta Capuzzo A., Villa V., Albarello L., Franchi GM, Gemma M., Scavini M., Di Palo S., Orsenigo E., Bos, Emanuele, Doglioni, Claudio, Manzoni MF.

Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.

THE JOURNAL OF CLINICAL INVESTIGATION, vol. 123, p. 5009-5022 (2013).

Caganova M., Carrisi C., Varano G., Mainoldi F., Zanardi F., Germain PL, George L., Alberghini F, Ferrarini L, Talukder AK, PONZONI , MAURILIO, Testa G, Nojima T, DOGLIONI , CLAUDIO, Kitamura D, Toellner KM, Su IH, Casola S.

Nodular lymphocyte predominant Hodgkin lymphoma with non-invasive or early invasive growth pattern suggests an early step of the disease with a highly favorable outcome.

AMERICAN JOURNAL OF HEMATOLOGY, vol. 88, p. 161-162

Carbone A., Spina M., Gloghini A., Ponzoni, Maurilio, Doglioni, Claudio, Tirelli U. (2013).