Stefano Previtali

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Specialty:

Neurology Rare Diseases

Profession:

Neurologist

Location:

Department of Neurology and Neurorehabilitation @ Ospedale San Raffaele

Languages:

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Biography

Dr. Stefano Previtali carries out his clinical activities in the Department of Neurology of the IRCCS Ospedale San Raffaele under the supervision of Professor Massimo Filippi.

After graduating from the University of Milan in Medicine and Surgery in 1990, he specialized in neurology in 1994 and received his PhD in Neurology from the same university in 1998.

Dr. Previtali is responsible for the Department of Muscle Biopsy (Morphological, Histoenzymatic, Immunohistochemical, and Western Blot) and is an expert in neuromuscular diseases, with special attention to myopathies (genetic and acquired) and genetic neuropathies (CMT) in both adults and in children.

In terms of research activities, Dr. Previtali is responsible for the Neuromuscular Regeneration Research Department. He is mainly engaged in identifying new therapeutic strategies and identifying the molecular mechanisms underlying some diseases, including: Duchenne muscular dystrophy, facioscapulo-brachial dystrophy, congenital dystrophy due to merosin deficiency (LAMA2), laminopathy, Charcot-Marie-Tooth disease (CMT).

He is the author and co-author of more than 100 publications in industry scientific journals and book sections. His Hirsch Index is 37. He constantly participates in national and international industry congresses.

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Rare diseases: high specialization and scientific research

What is Duchenne muscular dystrophy?

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Publications

Latest publications

Impaired turnover of hyperfused mitochondria in severe axonal neuropathy due to a novel DRP1 mutation.

Hum Mol Genet 2020 2020;29(2):177–188. doi: 10.1093/hmg/ddz211. PMID 31868880

Longo F, Benedetti S, Zambon AA, Natali Sora MG, Di Resta C, Quattrini A, Maltecca F, Ferrari M, Previtali SC.

Expanding the spectrum of genes responsible for hereditary motor neuropathies.

J Neurol Neurosurg Psychiatry. 2019;90(10):1171–1179.. doi: 10.1136/jnnp-2019-320717. PMID 31167812

Previtali SC, Zhao E, Lazarevic D, Pipitone GB, Fabrizi GM, Manganelli F, Mazzeo A, Pareyson D, Schenone A, Taroni F, Vita G, Bellone E, Ferrarini M, Garibaldi M, Magri S, Padua L, Pennisi E, Pisciotta C, Riva N, Scaioli V, Scarlato M, Tozza S, Geroldi A, Jordanova A, Ferrari M, Molineris I, Reilly MM, Comi G, Carrera P, Devoto M, Bolino A.

A multicentre retrospective study of Charcot-Marie-Tooth disease type 4B (CMT4B) due to mutations in Myotubularin-related proteins (MTMRs).

Ann Neurol. 2019;86(1):55–67. doi: 10.1002/ana.25500. PMID

Pareyson D, Stojkovic T, Reilly MM, Leonard-Louis S, Laurà M, Blake J, Parman Y, Battaloglu E, Tazir M, Bellatache M, Bonello-Palot N, Lévy N, Sacconi S, Guimarães-Costa R, Attarian S, Latour P, Solé G, Megarbane A, Horvath R, Ricci G, Choi BO, Schenone A, Gemelli C, Geroldi A, Sabatelli M, Luigetti M, Santoro L, Manganelli F, Quattrone A, Valentino P, Murakami T, Scherer SS, Dankwa L, Shy ME, Bac

Expanding The Central Nervous System Disease Spectrum Associated WITH Flnc Mutation. Muscle Nerve.

2019;59(5):E33–E37. doi: 10.1002/mus.26443. PMID 30734317

Previtali SC, Scarlato M, Vezzulli P, Ruggieri A, Velardo D, Benedetti S, Torini G, Colombo B, Maggi L, Bella DD, Gellera C, D'Angelo G, Mora M.

Diagnosis of Duchenne Muscular Dystrophy in Italy in the last decade: critical issues and areas for improvements.

Neuromuscul Disord. 2017 May;27(5):447-451. doi: 10.1016/j.nmd.2017.02.006. PMID:28262469

D'Amico A, Catteruccia M, Baranello G, Politano L, Govoni A, Previtali SC, Pane M, D'Angelo MG, Bruno C, Messina S, Ricci F, Pegoraro E, Pini A, Berardinelli A, Gorni K, Battini R, Vita G, Trucco F, Scutifero M, Petillo R, D'Ambrosio P, Ardissone A, Pasanisi B, Vita G, Mongini T, Moggio M, Comi GP, Mercuri E, Bertini E.

Niacin-mediated Tace activation ameliorates CMT neuropathies with focal hypermyelination.

EMBO Mol Med 2016 Dec 1;8(12):1438-1454. doi: 10.15252/emmm.201606349. PMID 27799291

Bolino A, Piguet F, Alberizzi V, Pellegatta M, Rivellini C, Guerrero-Valero M, Noseda R, Brombin C, Nonis A, D'Adamo P, Taveggia C, Previtali SC.

Intra-arterial transplantation of HLA-matched donor mesoangioblasts in Duchenne Muscular Dystrophy.

EMBO MolMed 2015 Nov 5. pii: e201505636. doi: 10.15252/emmm.201505636. PMID:26543057

Cossu G*, Previtali SC*, Napolitano S, Cicalese MP, Tedesco FS, Nicastro F, Noviello M, Roostalu U, Natali Sora MG, Scarlato M, De Pellegrin M, Godi C, Giuliani S, Ciotti F, Tonlorenzi R, Lorenzetti I, Rivellini C, Benedetti S, Gatti R, Marktel S, Mazzi B, Tettamanti A, Ragazzi M, Imro MA, Marano G, Ambrosi A, Fiori R, Sormani MP, Bonini C, Venturini M, Politi LS, Torrente Y*, Ciceri F*.

Mesoangioblast delivery of miniagrin ameliorates murine model of Merosin Deficient Congenital Muscular Dystrophy type 1A.

Skelet Muscle. 2015 Sep 3;5:30. doi: 10.1186/s13395-015-0055-5. eCollection 2015.. PMID:26347253

Domi T, Porrello E, Velardo D, Capotondo A, Biffi A, Tonlorenzi R, Amadio S, Ambrosi A, MiyagoeSuzuki Y, Takeda S, Ruegg MA, Previtali SC.

Muscle MRI findings in Facioscapulohumeral muscular dystrophy.

Eur Radiol. 2016 Mar;26(3):693-705. doi: 10.1007/s00330-015-3890-1. Epub 2015 Jun 27. PMID:26115655

Gerevini S, Scarlato M, Maggi L, Cava M, Caliendo G, Pasanisi B, Falini A, Previtali SC*, Morandi L.

A new double trouble phenotype: facioscapulohumeral muscular dystrophy ameliorates spastic paraparesis due to spastin mutation.

J Neurol. 2015 Feb;262(2):476-8. doi: 10.1007/s00415-014-7606-2. Epub 2014 Dec 16.PMID:25511172

Scarlato M, Nuara A, Gerevini S, Benedetti S, Rossi P, Ferrari M, Previtali SC.

Loss of function mutations in HINT1 are a major cause of peripheral neuropathy with neuromyotonia

Nat Genet. 2012 Oct;44(10):1080-3. doi: 10.1038/ng.2406. PMID 22961002

Zimoń M, Baets J, Almeida-Souza L, De Vriendt E, Nikodinovic J, Parman Y, Battalo Gcaron Lu E, Matur Z, Guergueltcheva V, Tournev I, Auer-Grumbach M, De Rijk P, Petersen BS, Müller T, Fransen E, Van Damme P, Löscher WN, Barišić N, Mitrovic Z, Previtali SC, Topalo Gcaron Lu H, Bernert G, BelezaMeireles A, Todorovic S, Savic-Pavicevic D, Ishpekova B, Lechner S, Peeters K, Ooms T, Hahn AF, Züchner S,

Importance of SPP1 genotype as a covariate in clinical trials in Duchenne muscular dystrophy.

Neurology 2012 Jul 10;79(2):159-62. PMID 22744661

Bello L, Piva L, Barp A, Taglia A, Picillo E, Vasco G, Pane M, Previtali SC, Torrente Y, Gazzerro E, Motta MC, Grieco GS, Napolitano S, Magri F, D'Amico A, Astrea G, Messina S, Sframeli M, Vita GL, Boffi P, Mongini T, Ferlini A, Gualandi F, Soraru' G, Ermani M, Vita G, Battini R, Bertini E, Comi GP, Berardinelli A, Minetti C, Bruno C, Mercuri E, Politano L, Angelini C, Hoffman EP, Pegoraro E.

Vimentin regulates peripheral nerve myelination.

Development 2012 Apr;139(7):1359-67. PMID 22357929

Triolo D, Dina G, Taveggia C, Vaccari I, Porrello E, Rivellini C, Domi T, La Marca R, Cerri F, Bolino A, Quattrini A, Previtali SC.

Functional changes in Duchenne muscular dystrophy: a 12-month longitudinal cohort study

Neurology 2011 Jul 19;77(3):250-6. PMID 21734183

Mazzone E, Vasco G, Sormani MP, Torrente Y, Berardinelli A, Messina S, Adele D’Amico, Doglio L, Politano L, Martinelli D, Cavallaro F, Frosini S, Bello L, Bonfiglio S, Zucchini E, De Sanctis R, Scutifero M, Bianco F, Rossi F, Motta MC, Sacco A, Donati MA, Mongini T, Pini A, Battini R, Pegoraro E, Pane M, Gasperini S, Previtali S, Napolitano S, Bruno C, Vita G, Comi GP, Bertini E, Mercuri E.

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