个人简介
Angelo Manfredi教授是IRCCS圣拉斐尔科学研究医院免疫学、风湿病学、过敏反应与罕见疾病科医疗协调员,在Lorenzo Dagna教授的指导下开展工作。
自2003年以来,Manfredi教授一直是该院免疫学、移植和传染病科下属的自身免疫和血管炎症研究部门负责人。自2004年起,他还一直担任米兰圣拉斐尔生命健康大学医学院的风湿病学副教授。
1985年,Manfredi教授获得米兰大学医学学位之后,1989年在该校获得变态反应学和临床免疫学专业学位。1987年至1992年,在明尼苏达大学圣保罗校区学习;1997年,在马赛吕米尼免疫学研究中心学习。
Manfredi教授的临床实践侧重于慢性自身免疫性疾病(系统性自身免疫性疾病、结缔组织疾病、系统性血管炎)患者,尤其关注相关风湿病损伤以及关节和血管损伤的管理。
Manfredi教授的研究活动重点关注系统性自身免疫性疾病、小血管炎和大血管炎。近年来,Manfredi教授与其合作者重点研究了血管炎症的潜在机制、自身免疫对组织修复机制的影响以及预后和器官受累生物标记物的鉴定。
Manfredi教授以作者或共同作者的身份在国际期刊上发表了240余篇科研论文。自1992年以来,所著论文引用次数高达15000余次,截至2020年7月,H指数为60(意大利顶级科学家列表:http://www.topitalianscientists.org/home)。他是Istituto Lombardo and Accademia di Scienze e Lettere研究所的通讯成员(http://www.istitutolombardo.it/)。
出版物
最新出版物
Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis.
Sci Transl Med. 2018 Jul 25;10(451). pii: eaao3089. doi: 10.1126/scitranslmed.aao3089.
Cytotoxic T Cells Is Expanded in Patients with IgG4-Related Disease and Decreases Following Glucocorticoid Treatment.
A CD8α- Subset of CD4+SLAMF7 ArthritisRheumatol. 2018 Jul; 70(7):1133-1143. doi: 10.1002/art.40469.
Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps.
Pharmacol Res. 2017 123:146-156. pii: S1043-6618(16)30619-3. doi: 10.1016/j.phrs.2016.08.008.
Chromogranin-A production and fragmentation in patients with Takayasu arteritis. Arthritis Res Ther.
2016 Aug 17;18:187. doi: 10.1186/s13075-016-1082-2
Anti-TNFα agents curb platelet activation in patients with rheumatoid arthritis Ann Rheum Dis.
2016 Aug;75(8):1511-20. doi: 10.1136/annrheumdis-2015-208442.
Clinical trials in rheumatology. Does one size fit all?
Rheumatology (Oxford). 2016 Jun 15. pii: kew253
Parietal and intravascular innate mechanisms of vascular inflammation.
Arthritis Res Ther. 2015 Jan 28;17:16. doi: 10.1186/s13075-015-0528-2.
TRPC6 gene variants and neuropsychiatric lupus.
J Neuroimmunol. 2015 Nov 15; 288:21-4. doi: 10.1016/j.jneuroim.2015.08.015.
Beta-adducin and sodium-calcium exchanger 1 gene variants are associated with systemic lupus erythematosus and lupus nephritis.
Rheumatol Int. 2015 Dec;35(12):1975-83. doi: 10.1007/s00296-015-3298-x
Instructive influences of phagocytic clearance of dying cells on neutrophil extracellular trap generation.
Clin Exp Immunol. 2015 Jan;179(1):24-9. doi:10.1111/cei.12320.
Oxidative stress elicits platelet/leukocyte inflammatory interactions via HMGB1: A Candidate for microvessel injury in sytemic sclerosis (2014)
Antioxidants and Redox Signaling, 20 (7), pp. 1060-1074
How macrophages ring the inflammation alarm
Proceedings of the National Academy of Sciences of the United States of America, 111 (8), pp. 2866-2867
Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps.
J Thromb Haemost. 2014 Dec;12(12):2074-88.
Systemic pentraxin-3 levels reflect vascular enhancement and progression in Takayasu arteritis.
Arthritis Res Ther. 2014 Nov 14;16(6):479. doi: 10.1186/s13075-014-0479.
Procalcitonin in Takayasu arteritis.
J Rheumatol. 2014 Jul;41(7):1564-6. doi:10.3899/jrheum.131340