Samuele Burastero
个人简介
Samuele Burastero医生是IRCCS圣拉斐尔科学研究医院免疫学、风湿病学、过敏反应与罕见疾病科的免疫学家，在Lorenzo Dagna教授的指导下开展工作。
1982年毕业于热那亚大学医学院，1985年专攻呼吸病理生理学，1993年在同一所大学专攻变态反应学。
临床上，Burastero医生在科室门诊作为过敏症专科医生开展活动。
在研究活动方面，Burastero医生负责细胞和分子变态反应学研究组。
在这方面，他长期研究过敏性哮喘的Th2炎症和过敏原特异性免疫治疗（ASIT）的机制。目前，他的研究活动集中于使用基于蛋白质组学的方法监测ASIT的生物学参数的研究；他还参与了旨在确定对用于治疗严重哮喘的生物药物有反应的个体的项目。
Burastero医生还于2003年启动了与化学工业的联合项目，迄今为止活跃在免疫毒性部门，其中进行了体外试验，以预测化学品的致敏潜力。
他以作者或共同作者的身份在意大利国内外学术期刊上发表了100多篇文章，也参与了多个书籍章节的编写。H指数为35。多次作为发言人参加意大利国内外的行业会议。
出版物
最新出版物
Thermal stability, ligand binding and allergenicity data of Mus m 1.0102 allergen and its cysteine mutants.
Data Brief. 2020 Feb 29;29:105355. doi: 10.1016/j.dib.2020.105355. PMID: 32190721; PMCID: PMC7068051.
The allergen Mus m 1.0102: Cysteine residues and molecular allergology.
Mol Immunol. 2020 Apr;120:1-12. doi: 10.1016/j.molimm.2020.01.022. Epub 2020 Feb 7. PMID: 32044430.
T-cell receptor-mediated cross-reactivity to different allergens is driven by recognition of homologous, phylogenetically conserved epitopes
J Allergy Clin Immunol. 2016 Oct;138(4):1237. doi: 10.1016/j.jaci.2016.04.055. Epub 2016 Jul 30. PMID: 27484036.
Serum diamine oxidase activity in patients with histamine intolerance.
Int J Immunopathol Pharmacol. 2016 Mar;29(1):105-11. doi: 10.1177/0394632015617170. Epub 2015 Nov 16. PMID: 26574488; PMCID: PMC5806734.
Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: a randomized, open, parallel-group study.
Ann Allergy Asthma Immunol. 2014 Dec;113(6):671-673.e1. doi: 10.1016/j.anai.2014.09.009. Epub 2014 Oct 7. PMID: 25304342.
Phleum pratense manganese superoxide dismutase identified by proteomic: a new candidate grass allergen.
Ann Allergy Asthma Immunol. 2014 Mar;112(3):261. doi: 10.1016/j.anai.2013.12.015. Epub 2014 Jan 10. PMID: 24428968.
Aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1): the member of a molecular hub with unexpected functions, including CD4 T cell homeostasis.
Clin Immunol. 2012 Jun;143(3):207-9. doi: 10.1016/j.clim.2012.03.006. Epub 2012 Apr 6. PMID: 22542741.
In search of a vaccine for mouse allergy: significant reduction of Mus m 1 allergenicity by structure-guided single-point mutations.
Int Arch Allergy Immunol. 2012;157(3):226-37. doi: 10.1159/000327551. Epub 2011 Oct 27. PMID: 22041937
Broad-spectrum inhibition of HIV-1 by a monoclonal antibody directed against a gp120-induced epitope of CD4.
PLoS One. 2011;6(7):e22081. doi: 10.1371/journal.pone.0022081. Epub 2011 Jul 19. PMID: 21818294; PMCID: PMC3139607.
Human monocytoid THP-1 cell line versus monocyte-derived human immature dendritic cells as in vitro models for predicting the sensitising potential of chemicals.
Int J Immunopathol Pharmacol. 2007 Apr-Jun;20(2):259-65. doi: 10.1177/039463200702000206. PMID: 17624238.
Three-year follow-up of clinical and inflammation parameters in children monosensitized to mites undergoing sub-lingual immunotherapy.
Pediatr Allergy Immunol. 2005 Sep;16(6):519-26. doi: 10.1111/j.1399-3038.2005.00301.x. Erratum in: Pediatr Allergy Immunol. 2006 Jun;17(4):318. PMID: 16176400.