Sarah Marktel

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Specialty:

Hematology Hematology and Bone Marrow Transplantation in Adults Oncology

Profession:

Hematologist

Location:

Department of Hematology and Bone Marrow Transplantation @ Ospedale San Raffaele

Languages:

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Biography

Dr. Sarah Marktel is responsible for the treatment of patients with hereditary anemia in the Operative Department of Hematology and Bone Marrow Transplantation at the IRCCS Ospedale San Raffaele under the supervision of Professor Fabio Ciceri.

After graduating in 1997 from the Faculty of Medicine and Surgery of the University of Milan, she specialized in Hematology in 2002 at the University of Pavia. Over the years, she has been undergoing various internships abroad, in particular, at major London University hospitals (Membership Royal College Physicians, London, UK).

Dr. Marktel helps hematological patients in their treatment in the hematology day hospital, in particular patients with leukemia, myeloma, spinal cord aplasia and congenital anemia. This also includes patients who have undergone autologous and allogeneic bone marrow transplantation during their treatment.

As for research activities, she is mainly engaged in gene therapy of thalassemia.

She is the author and co-author of more than 70 publications in industry scientific journals. She constantly participates in national and international congresses of the industry.

Education

University of Milan
Diploma Course in Medicine and Surgery - 1997

University of Pavia
Specialization in Hematology - 2002

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Publications

Latest publications

Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ßthalassemia.

Nat Med. 2019 Feb;25(2):234-241.

Marktel S, Scaramuzza S, Cicalese MP, Giglio F, Galimberti S, Lidonnici MR, Calbi V, Assanelli A, Bernardo ME, Rossi C, Calabria A, Milani R, Gattillo S, Benedicenti F, Spinozzi G, Aprile A, Bergami A, Casiraghi M, Consiglieri G, Masera N, D'Angelo E, Mirra N, Origa R, Tartaglione I, Perrotta S, Winter R, Coppola M, Viarengo G, Santoleri L, Graziadei G, Gabaldo M, Valsecchi MG, Montini E, Naldini

Elderly patients > 65 years of age with acute myeloid leukemia and normal karyotype benefit from intensive therapeutic programs.

Am J Hematol. 2016 Jun;91(6):E302-3.

Bernardi M, Carrabba M, Messina C, Milani R, Sala E, Pavesi F, Gentner B, Peccatori J, Assanelli A, Marktel S, Corti C, Forcina A, Vago L, Ciceri F.

Hemopoietic stem cell transplantation in thalassemia: a report from the European Society for Blood and Bone Marrow Transplantation Hemoglobinopathy Registry, 2000- 2010.

Bone Marrow Transplant. 2016 Apr;51(4):536-41.

Baronciani D, Angelucci E, Potschger U, Gaziev J, Yesilipek A, Zecca M, Orofino MG, Giardini C, Al-Ahmari A, Marktel S, de la Fuente J, Ghavamzadeh A, Hussein AA, Targhetta C, Pilo F, Locatelli F, Dini G, Bader P, Peters C.

High rate of hematological responses to sorafenib in FLT3- ITD acute myeloid leukemia relapsed after allogeneic hematopoietic stem cell transplantation.

Eur J Haematol. 2015

De Freitas T, Marktel S, Piemontese S, Carrabba MG, Tresoldi C, Messina C, Lupo Stanghellini MT, Assanelli A, Corti C, Bernardi M, Peccatori J, Vago L, Ciceri F

Post-transplantation Cyclophosphamide and Sirolimus after Haploidentical Hematopoietic Stem Cell Transplantation Using a Treosulfan-based Myeloablative Conditioning and Peripheral Blood Stem Cells.

Biol Blood Marrow Transplant 2015

Cieri N, Greco R, Crucitti L, Morelli M, Giglio F, Levati G, Assanelli A, Carrabba MG, Bellio L, Milani R, Lorentino F, Stanghellini MT, De Freitas T, Marktel S, Bernardi M, Corti C, Vago L, Bonini C, Ciceri F, Peccatori J.

Treosulfan based reduced toxicity conditioning followed by allogeneic stem cell transplantation in patients with myelofibrosis.

Hematol Oncol. 2014

Claudiani S, Marktel S, Piemontese S, Assanelli A, Lupo-Stanghellini MT, Carrabba M, Guggiari E, Giglio F, De Freitas T, Marcatti M, Bernardi M, Corti C, Peccatori J, Lunghi F, Ciceri F

Incidence, risk factors and clinical outcome of leukemia relapses with loss of the mismatched HLA after partially incompatible hematopoietic stem cell transplantation.

Leukemia. 2015

Crucitti L, Crocchiolo R, Toffalori C, Mazzi B, Greco R, Signori A, Sizzano F, Chiesa L, Zino E, Lupo Stanghellini MT, Assanelli A, Carrabba MG, Marktel S, Marcatti M, Bordignon C, Corti C, Bernardi M, Peccatori J, Bonini C, Fleischhauer K, Ciceri F, Vago L

Sirolimus-based graft-versus-host disease prophylaxis promotes the in vivo expansion of regulatory T cells and permits peripheral blood stem cell transplantation from haploidentical donors.

Leukemia. 2014 Jun 4

Peccatori J, Forcina A, Clerici D, Crocchiolo R, Vago L, Stanghellini MT, Noviello M, Messina C, Crotta A, Assanelli A, Marktel S, Olek S, Mastaglio S, Giglio F, Crucitti L, Lorusso A, Guggiari E, Lunghi F, Carrabba M, Tassara M, Battaglia M, Ferraro A, Carbone MR, Oliveira G, Roncarolo MG, Rossini S, Bernardi M, Corti C, Marcatti M, Patriarca F, Zecca M, Locatelli F, Bordignon C, Fleischhauer K,

Unpredictability of iv Busulfan pharmacokinetics in children undergoing hematopoietic stem cell transplant for advanced beta thalassemia: Limited toxicity with a dose adjustment policy.

Biol Blood Marrow Transplant. 2009

Chiesa R, Cappelli B, Crocchiolo R, Frugnoli I, Biral E, Noè A, Evangelio C, Fossati M, Roccia T, Biffi A, Finizio V, Aiuti A, Broglia M, Bartoli A, Ciceri F, Roncarolo MG, Marktel S

Gene therapy for immunodeficiency due to adenosine deaminase deficiency.

N Engl J Med. 2009 Jan 29;360(5):447-58.

Aiuti A, Cattaneo F, Galimberti S, Benninghoff U, Cassani B, Callegaro L, Scaramuzza S, Andolfi G, Mirolo M, Brigida I, Tabucchi A, Carlucci F, Eibl M, Aker M, Slavin S, Al-Mousa H, Al Ghonaium A, Ferster A, Duppenthaler A, Notarangelo L, Wintergerst U, Buckley RH, Bregni M, Marktel S, Valsecchi MG, Rossi P, Ciceri F, Miniero R, Bordignon C, Roncarolo MG.

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