Alessandro Aiuti

职业:
血液科医生
语言:
EN
IT

个人简介

Alessandro Aiuti教授是米兰IRCCS圣拉斐尔科学研究医院小儿免疫血液病科主任,以及圣拉斐尔生命健康大学的儿科教授。此外,他还是圣拉斐尔基因治疗Telethon研究所(SR-Tiget)的副主任,以及该研究所原发性免疫缺陷发病机制和治疗研究单位的负责人。

Aiuti教授毕业于罗马大学医学院,并在该校获得了分子和细胞生物学博士学位。1998年,获得米兰大学血液学专业学位。

Aiuti教授的临床工作和研究主要涉及儿科血液学和免疫学,尤其专注于原发性免疫缺陷和其他遗传性疾病及其基因和细胞疗法的研究。Aiuti教授曾取得众多令人瞩目的研究成果,其中包括ADA-SCID基因治疗临床试验,这是全球首个获批上市的造血(或血液)干细胞基因疗法。

Aiuti教授在ScienceNew England Journal of Medicine、Nature Medicine、Journal of Clinical InvestigationBloodEMBO Molecular MedicineScience Translational Medicine等期刊上发表了180余篇科研论文(Scopus中H指数为48,影响因子为1.509)。他还是NatureBloodThe Journal of Allergy and Clinical Immunology等期刊的审稿人。

在研究方面,Aiuti教授曾荣获众多奖项,例如,2005年曾凭借杰出的职业生涯和开创性的贡献获得欧洲细胞和基因治疗学会颁发的奖项。他是欧洲药品管理局(EMA)先进疗法委员会(CAT)、欧洲血液和骨髓移植学会(EBMT)研究委员会先天性缺陷工作组(IEWP)以及意大利免疫缺陷(IPINET)与ASGCT血液和免疫基因和细胞治疗工作组的成员。

教育背景

罗马大学
医学学位 - 1990年

罗马大学
分子和细胞生物学博士学位 - 1996年

米兰大学
血液学专业学位 - 1998年

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出版物

Aiuti教授在ScienceNew England Journal of Medicine、Nature Medicine、Journal of Clinical InvestigationBloodEMBO Molecular MedicineScience Translational Medicine等期刊上发表了180余篇科研论文(Scopus中H指数为48,影响因子为1.509)。他还是NatureBloodThe Journal of Allergy and Clinical Immunology等期刊的审稿人

最新出版物

Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia.
Nat Med (2019) 25:234-241.
Marktel S., Scaramuzza S., Cicalese M.P., Giglio F., Galimberti S., Lidonnici M.R., Calbi V., Assanelli A., Bernardo M.E., Rossi C., Calabria A., Milani R., Gattillo S., Benedicenti F., Spin
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Lentiviral haematopoietic stem/progenitor cell gene therapy for the treatment of Wiskott-Aldrich syndrome: interim results of a non-randomized, open-label, phase 1/2 clinical study.
Lancet Hematology (2019) 6: e239-e253. Epub 2019 April 10.
Ferrua F., Cicalese M.P., Galimberti S., Giannelli S., Dionisio F., Barzaghi F., Migliavacca M., Bernardo M.E., Calbi V., Assanelli A.A., Facchini M., Fossati C., Albertazzi E., Scaramuzza S
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Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial.
Lancet (2016) 388: 476-487. Epub June 8, 2016.
Sessa M, Lorioli L, Fumagalli F, Acquati S, Redaelli D, Baldoli C, Canale S, Lopez ID, Morena F, Calabria A, Fiori R, Silvani P, Rancoita PM, Gabaldo M, Benedicenti F, Antonioli G, Assanelli
Dynamics of hematopoietic stem/progenitor cells after autologous transplantation in humans.
Nat Med (2018) 24:1683-1690. Epub 2018 Oct 1
Scala S., Basso-Ricci L., Dionisio F., Pellin D., Giannelli S., Salerio F.A., Leonardelli L., Cicalese M.P., Ferrua F., Aiuti A., and Biasco L.
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Lentiviral vector gene therapy protects XCGD mice from Acute Staphylococcus aureus pneumonia and inflammatory response.
Mol Ther. (2016) 24: 1873-1880.
Farinelli G., Hernandez RJ, Rossi A, Ranucci S, Sanvito F, Migliavacca M,Brombin C, Pramov A, Serio CD, Bovolenta C, Gentner B, Bragonzi A,and Aiuti A.
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Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency.
Blood (2016) 128: 45-54. Epub April 29, 2016.
Cicalese M.P., Ferrua F., Castagnaro L., Pajno R., Barzaghi F., Giannelli S., Dionisio F., Brigida I., Bonopane M., Casiraghi M., Tabucchi A., Carlucci F., Grunebaum E., Adeli M., Bredius R.G., Puck J.M., Stepensky P., Tezcan I., Rolfe K., De Boever E., Reinhardt R.R., Appleby J., Ciceri F., Roncarolo M.G., and Aiuti A.
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In vivo tracking of human hematopoiesis reveals patterns of clonal dynamics during early and steady-state seconstitution phases.
Cell Stem Cell (2016) 19: 107-119. Epub May 25, 2016.
Biasco L., Pellin D., Scala S., Dionisio F., Basso-Ricci L.,Leonardelli L., Scaramuzza S., Baricordi C., Ferrua F., Cicalese M.P., Giannelli S., Neduva V., Dow D.J., Schmidt M., Von Kalle C.,Roncarolo M.G., Ciceri F., Vicard P., Wit E., Di Serio C., Naldini L., and Aiuti A.
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In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells.
Sci Transl Med (2015) 7: 273ra13.
Biasco L., Scala S., Basso Ricci L., Dionisio F., Baricordi C., Calabria A., Giannelli S., Cieri N., Barzaghi F., Pajno R., Al-Mousa H., Scarselli A., Cancrini C., Bordignon C., Roncarolo M.G., Monti E., Bonini C., and Aiuti A.
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Dual-regulated lentiviral vector for gene therapy of X-linked chronic granulomatosis.
Mol Ther. (2014) 22: 1472-1483. Epub 2014 May 29.
Chiriaco M., Farinelli G., Capo V., Di Matteo G., Zonari E., Scaramuzza S., Sergi Sergi L., Migliavacca M.,Hernandez R.J., Bombelli F., Giorda E., Kajaste-Rudnitski A., Trono D., Grez M., Rossi P., Finocchi A., Naldini L., Gentner B., and Aiuti A.
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Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy.
Science (2013) 341(6148):1233158. Epub 2013 Jul 11.
Biffi A., Montini E., Lorioli L., Cesani M., Fumagalli F., Plati T., Baldoli C., Martino S., Calabria A., Canale S., Benedicenti F., Vallanti G., Biasco L., Leo S., Kabbara N., Zanetti G., Rizzo W.B., Mehta N., Cicalese M.P., Casiraghi M., Boelens J.J., Del Carro U., Dow D.J., Schmidt M., Assanelli A., Neduva V., Di Serio C., Stupka E., Gardner J., Van Kalle C., Bordignon C., Ciceri F., Rovelli A.
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