Lorenzo Piemonti

Lorenzo Piemonti
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Specialty:
Endocrinology Adult Endocrinology Diabetes (Adults) Regenerative Medicine Transplant Medicine
+2
Profession:
Endocrinologist
Languages:
EN
IT
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Biography

Professor Lorenzo Piemonti is the Head of the Regenerative Medicine and Transplant Unit at the IRCCS Ospedale San Raffaele.

At the IRCCS Ospedale San Raffaele, the professor is also the Director of the Diabetes Research Institute and the head of the Human Island Transplantation program. However, in the academic field, he is an associate professor of endocrinology at the Vita-Salute San Raffaele University in Milan and a visiting professor at the Free University of Brussels.

After graduating from the Faculty of Medicine and Surgery of the University of Milan in 1994, he received a specialization in endocrinology and diseases associated with metabolic disorders in 2000, and in 2004 – in microsurgery and experimental surgery at the same university.

Professor Piemonti's clinical activities cover clinical endocrinology (thyroid gland, obesity, etc.), pays special attention to diabetes in all its clinical forms, tissue transplantation and regenerative medicine.

From the point of view of research, the professor focuses mainly on diabetes and pancreatology, in particular, on the human islet transplantation model and the biology of pancreatic cancer. In addition, beta cell replacement, immune tolerance induction strategies, dendritic cell and stem cell biology are also of interest to Professor Piemonti's research.

He is the author of more than 250 original scientific articles published in international journals. His Hirsch index is 61. He constantly participates as a speaker and moderator at national and international industry conferences.

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Publications

Latest publications

Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes. Diabetes Care.
2020 Feb 4. pii: dc191480. doi: 10.2337/dc19-1480. [Epub ahead of print] PubMed PMID: 32019854.
Maffi P, Lundgren T, Tufveson G, Rafael E, Shaw JAM, Liew A, Saudek F, Witkowski P, Golab K, Bertuzzi F, Gustafsson B, Daffonchio L, Ruffini PA, Piemonti L; and the REP0211 Study Group; REP0211 Study Group.
Reduced PD-1 expression on circulating CXCR5(+) and CXCR5(-) FOXP3(+) Treg cells marks type 1 diabetes initiation in children.
Clin Immunol. 2019 Nov 30:108319. doi: 10.1016/j.clim.2019.108319. [Epub ahead of print] PubMed PMID: 31794865.
Vecchione A, Gerosa J, Di Fonte R, Jofra T, Pia CM, Napoleone V, Ippolito E, Galvani G, Ragogna F, Stabilini A, Bianconi E, Grogan P, Bonura C, Bonfanti R, Frontino G, Nano R, Melzi R, De Pellegrin M, Laurenzi A, Meschi F, Barera G, Rigamonti A, Indirli R, Bosi E, Piemonti L, Aiuti A, Battaglia M, Fousteri G.
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes. Nat Genet
2019 Nov 1. doi: 10.1038/s41588-019-0524-6. [Epub ahead of print] PubMed PMID: 31676868.
Ramos-Rodríguez M, Raurell-Vila H, Colli ML, Alvelos MI, Subirana-Granés M, Juan-Mateu J, Norris R, Turatsinze JV, Nakayasu ES, Webb-Robertson BM, Inshaw JRJ, Marchetti P, Piemonti L, Esteller M, Todd JA, Metz TO, Eizirik DL, Pasquali L.
Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses
Int J Mol Sci 2019 Oct 8;20(19). pii: E4962. doi: 10.3390/ijms20194962. Review. PubMed PMID: 31597342; PubMed CentralPMCID: PMC6801424.
Di Dedda C, Vignali D, Piemonti L, Monti P.
Selective local irradiation improves islet engraftment and survival in intra-bone marrow islet transplantation
Cytotherapy. 2019 Aug 20. pii: S1465-3249(19)30821-7. doi: 10.1016/j.jcyt.2019.07.005. [Epub ahead of print] PubMed PMID: 31444049.
Pellegrini S, Cantarelli E, Citro A, Incerti E, Piemonti L§, Sordi V§.
Heterogeneity of human pancreatic islet isolation around Europe: results of a survey study
Transplantation. 2019 Jul 17. doi: 10.1097/TP.0000000000002777. [Epub ahead of print] PubMed PMID: 31365472.
Nano R, Kerr-Conte JA, Scholz H, Engelse M, Karlsson M, Saudek F, Bosco D, Antonioli B, Bertuzzi F, Johnson PRV, Ludwing B, Ling Z, De Paep DL, Keymeulen B, Pattou F, Berney T, Korsgren O, de Koning E, Piemonti L.
Islet Transplantation
South Dartmouth (MA): MDText.com, Inc.; 2000-.PubMed PMID: 25905200.
Piemonti L. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP,
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Nothing Is Perfect, but We Can Do Better
Diabetes. 2019 Aug;68(8):1541-1543. doi: 10.2337/db19-0367. PubMed PMID: 31331988.
Nano R, Kerr-Conte JA, Bosco D, Karlsson M, Lavallard V, Melzi R, Gmyr V, Mercalli A, Berney T, Pattou F, Korsgren O, Piemonti L. Islets for Research.
CCL2/MCP-1 and CXCL12/SDF-1 BLOCKADE BY L-aptamers IMPROVE PANCREATIC ISLET ENGRAFTMENT AND SURVIVAL IN MOUSE
Am J Transplant. 2019 Jul 3. doi: 10.1111/ajt.15518. [Epub ahead of print] PubMed PMID: 31267721.
Citro A, Pellegrini S, Dugnani E, Eulberg D, Klussmann S, Piemonti L.
Human pancreatic islet threedimensional chromatin architecture provides insights into the genetics of type 2 diabetes
Nat Genet. 2019 Jul;51(7):1137-1148. doi: 10.1038/s41588-019-0457-0. Epub 2019 Jun 28. PubMed PMID: 31253982.
Miguel-Escalada I, Bonàs-Guarch S, Cebola I, Ponsa-Cobas J, Mendieta-Esteban J, Atla G, Javierre BM, Rolando DMY, Farabella I, Morgan CC, García-Hurtado J, Beucher A, Morán I, Pasquali L, Ramos- Rodríguez M, Appel EVR, Linneberg A, Gjesing AP, Witte DR, Pedersen O, Grarup N, Ravassard P, Torrents D, Mercader JM, Piemonti L, Berney T, de Koning EJP, Kerr-Conte J, Pattou F, Fedko IO, Groop L, Prokopenko I, Hansen T, Marti-Renom MA, Fraser P, Ferrer J.
Low-Carb and Ketogenic Diets in Type 1 and Type 2 Diabetes. Nutrients
2019 Apr 26; 11(5). pii: E962.doi: 10.3390/nu11050962. Review. PubMed PMID: 31035514
Bolla AM, Caretto A, Laurenzi A, Scavini M, Piemonti L.
Glucose metabolism during tumorigenesis in the genetic mouse model of pancreatic cancer
Acta Diabetol. 2019 Sep;56(9):1013-1022. doi: 10.1007/s00592-019-01335-4. Epub 2019 Apr 15.
Pasquale V, Dugnani E, Liberati D, Marra P, Citro A, Canu T, Policardi M, Valla L, Esposito A, Piemonti L.
Biofabrication of a vascularized islet organ for type 1 diabetes.
Biomaterials 2019 Apr;199:40-51. doi: 10.1016/j.biomaterials.2019.01.035. Epub 2019 Jan 24.
Citro A, Moser PT, Dugnani E, Rajab TK, Ren X, Evangelista-Leite D, Charest JM, Peloso A, Podesser BK, Manenti F, Pellegrini S, Piemonti L§, Ott HC§.
Inhibition of Eph/ephrin interaction with the small molecule UniPR500 improves glucose tolerance in healthy and insulin-resistant mice.
Pharmacol Res. 2019 Jan 6;141:319-330. doi: 10.1016/j.phrs.2019.01.011.
Giorgio C, Incerti M, Pala D, Russo S, Chiodelli P, Rusnati M, Cantoni AM, Di Lecce R, Barocelli E, Bertoni S, Ravassard P, Manenti F, Piemonti L, Ferlenghi F, Lodola A, Tognolini M.
Measurement of Autoantibodies to Gastric H+,K+-ATPase (ATP4A/B) Using a Luciferase Immunoprecipitation System (LIPS)
Methods Mol Biol. 2019;1901:113-131.
Lahner E, Marzinotto I, Brigatti C, Davidson H, Wenzlau J, Piemonti L, Annibale B, Lampasona V.
Diabetes-free survival after extended distal pancreatectomy and islet auto transplantation for benign or borderline/malignant lesions of the pancreas
Am J Transplant. 2019 Mar;19(3):920-928
Balzano G, Maffi P, Nano R, Mercalli A, Melzi R, Aleotti F, De Cobelli F, Magistretti P, Scavini M, Secchi A, Falconi M, Piemonti L.

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