Martino Gianvito

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Specialty:

Neurology

Profession:

Neurologist

Location:

Department of Neurology and Neurorehabilitation @ Ospedale San Raffaele

Languages:

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Biography

Born in Bergamo in 1962, he graduated from the Faculty of Medicine and Surgery of the University of Pavia in 1987, where he specialized in neurology in 1991. From 1990 to 1992 he did research abroad at the Department of Neurology at the Karolinska Institute in Stockholm and at the Department of Neurology at the University of Chicago.

At the Istituto Scientifico San Raffaele in Milan, he headed the Department of Neuroimmunology from 1997 to 2008 and the Department of Neurology from 2008 to 2016, and from 2016 to 2020 he held the position of Scientific Director. Already Professor Emeritus at the School of Medicine and Dentistry at Queen Mary University of London, he is Professor in Applied Biology and Vice-Chancellor for "Third Mission" Research at the Vita Salute San Raffaele University in Milan.

He was a founding member of the Italian Association of Neuroimmunology (AINI), of which he was President from 2009 to 2012, and of the European School of Neuroimmunology (ESNI) and the Global Schools of Neuroimmunology (GSNI), of which he is a member, now – scientific coordinator. From 2010 to 2012 he was Vice President and from 2012 to 2014 he was President of the International Society for Neuroimmunology (ISNI). He has been a member of the Scientific Council of a number of national and international scientific societies, including the UK Multiple Sclerosis Society, Wellcome Trust's Peer Review College, INSERM, ECTRIMS, FISM and MSIF. From 2017 to 2019, he was Chairman of the Scientific and Technical Committee of the Regional Biomedical Research Foundation (RBRF). Since 2015, he has been a member of the European Research Council (ERC), and since 2020 – NEURON-ERANET. Over the years, he has received numerous scientific awards, including the Rita Levi-Montalcini Award.

His scientific interests, which resulted in the publication of more than 250 scientific articles, range from the study of the pathogenetic mechanisms underlying immune-mediated diseases of the central nervous system to the development of gene therapy and innovative methods for the treatment of diseases of the nervous system by neural stem cells.

Education

University of Pavia
Degree of Doctor of Medicine and Surgery - 1987

University of Pavia
Specialization in Neurology - 1991

Multimedia gallery

Identified: the brain cell that regulates our decisions

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Publications

Latest publications

Injection of adult neurospheres induce clinical recovery in a chronic model of multiple sclerosis.

Nature 2003;422:688-694

Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani g, Dina G, Galli r, Bergami A, Furlan F, Delcarro U, Amadio S, Comi G, Vescovi AL, Martino G.

How the brain repairs itself: perspectives for new therapeutic strategies for inflammatory and degenerative CNS disorders.

Lancet Neurol. 2004;3:372-378

Martino G

Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism.

Nature 2005;436:266-271.

Pluchino S, Zanotti l, Rossi b, Brambilla e, Ottoboni l, Salani g, Martinello m, Cattalini A, Bergami A, Furlan R, Comi G, Constantin G, Martino G

The therapeutic potential of neural stem cells.

Nat. Rev. Neurosci. 2006;7:395-406.

Martino G, Pluchino S.

Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis.

J. Neurosci. 2009;29:3442-3452

Centone D*, Muzio L*, Rossi S, Cavasinni F, De Chiara V, Bergami A, Musella A, Marcello d’amelio M, Cavallucci V, Martorana A, Bergamaschi A, Concioni MT, Diamantini A, Butti E, Comi G, Bernardi G, Cecconi F, Battistini L, Furlan R, Martino G.

Delayed post-ischemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms.

Brain 2009;132:2239-2251

Bacigaluppi M*, Pluchino S*, Kilic E, Peruzzotti-Jametti L, Kilic U, Salani G, Brambilla E, Comi G, Martino G*, Hermann DM*.

Human neural stem cells ameliorate autoimmune encephalomyelitis in non human primates.

Ann. Neurol. 2009;66:343-354

Pluchino S*, Gritti A*, Blazer E, Amadio S, Brambilla E, Borsellino G, Cossetti C, Del Carro U, Comi G, ‘T Hart B, Vescovi A, Martino G

the Stem Cells in Multiple Sclerosis (STEMS) Consensus Group. Stem cell transplantation in multiple sclerosis: current status and future prospects.

Nat. Rev. Neurol. 2010;6:247-255.

Martino G, Franklin RJ, Van Evercooren AB, Kerr DA,

Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitoxicity.

Brain 2012;115:3320-3335.

Butti E, Bacigaluppi M, Rossi S, Cambiaghi M, Bari M, Cebrian Silla A, Brambilla E, Musella A, De Ceglia R, Teneud L, De Chiara V, D’adamo P, Garcia-Verdugo JM, Comi G, Muzio L, Quattrini A, Leocani L, Maccarrone M, Centonze D, Martino G.

Cross-talk between neural stem cells and immune cells: the key to better brain repair?

Nat. Neurosci. 2012;15:1078-1087

Kokaia Z*, Martino G*, Schwartz M*, Lindvall O

Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitoxicity.

Brain 2012;115:3320-3335

Butti E*, Bacigaluppi M*, Rossi S, Cambiaghi M, Bari M, Cebrian Silla A, Brambilla E, Musella A, De Ceglia R, Teneud L, De Chiara V, D’adamo P, Garcia-Verdugo JM, Comi G, Muzio L, Quattrini A, Leocani L, Maccarrone M, Centonze D, Martino G.

iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of leukemia inhibitory factor.

Nat. Commun. 2013;4:2597

Laterza C, Merlini A, De Feo D, Ruffini F, Menon R, Onorati M, Fredrickx E, Muzio L, Lombardo A, Comi G, Quattrini A, Taveggia C, Farina C, Cattaneo E, Martino G

Neural stem cell transplantation promotes post-ischemic neuronal plasticity by regulating the expression of glutamate transporters.

J. Neurosci. 2016;36:10529

Bacigaluppi M, Russo G*, Peruzzotti-Jametti L*, Rossi S, Sandrone S, Gallizioli M, De Ceglia R, Butti E, Studer V, Colombo E, Reitmeir R, Motta C, Muzio L, Comi G, Farina C, Letterio Politi LS, Invernizzi RW, Hermann DM*, Centonze D*, Martino G

Neural precursor cell-secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity.

J. Clin. Inv. 2017;127:3937-3953 Epub ahead of print on September 25, 2017

De Feo D, Merlini A, Brambilla E, Ottoboni L, Laterza C, Menon R, Srinivasan S, Farina C, Manteiga Jmg, Butti E, Bacigaluppi M, Comi G, Greter M, Martino G

Neural stem cells of the subventricular zone contribute to neuroprotection of the corpus callosum after cuprizone-induced demyelination.

J. Neurosci. 2019;39:5481-5492 [Epub ahead of print on May 28, 2019]

Butti E, Bacigaluppi M, Chaabane L, Ruffini F, Brambilla E, Berera G, Montonati C, Quattrini A, Martino G

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