Martino Gianvito

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Specialty:

Neurology

Profession:

Neurologist

Location:

Department of Neurology and Neurorehabilitation @ Ospedale San Raffaele

Languages:

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Biography

Professor Gianvito Martino is a neurologist, Scientific Director of IRCCS San Raffaele Hospital, and Full Professor of Applied Biology as well as Vice-Rector for Research and the Third Mission at Vita-Salute San Raffaele University.

In 1987, he graduated in Medicine and Surgery from the University of Pavia, where he also specialized in Neurology in 1991. From 1990 to 1992, he conducted research abroad at the Department of Neurology of the Karolinska Institute in Stockholm and the Department of Neurology at the University of Chicago.

At the San Raffaele Scientific Institute in Milan, he led the Neuroimmunology Unit from 1997 to 2008 and the Neuroscience Division from 2008 to 2016. From 2016 to 2020, he served as Scientific Director. A former Honorary Professor at the School of Medicine and Dentistry at Queen Mary University of London, he is currently a Full Professor of Applied Biology and Vice-Rector for Research and the Third Mission at Vita-Salute San Raffaele University in Milan.

He co-founded the Italian Association of Neuroimmunology (AINI), serving as its President from 2009 to 2012, as well as the European School of Neuroimmunology (ESNI) and the Global Schools of Neuroimmunology (GSNI), where he remains Scientific Coordinator. From 2010 to 2012, he served as Vice President, and from 2012 to 2014, he was President of the International Society of Neuroimmunology (ISNI). He has been a member of the scientific boards of numerous national and international scientific organizations, including the UK Multiple Sclerosis Society, Wellcome Trust's Peer Review College, INSERM, ECTRIMS, FISM, and MSIF. From 2017 to 2019, he was President of the Technical Scientific Committee of the Regional Foundation for Biomedical Research (FRRB). Since 2015, he has been a Panel Member of the European Research Council (ERC) and, since 2020, of NEURON-ERANET. Over the years, he has received numerous scientific awards, including the Rita Levi-Montalcini Prize.

His scientific interests, reflected in the publication of over 250 scientific articles, range from studying the pathogenic mechanisms underlying immune-mediated central nervous system disorders to developing gene therapy tools and innovative therapies using neural stem cells to treat these conditions.

Education

University of Pavia
Degree of Doctor of Medicine and Surgery - 1987

University of Pavia
Specialization in Neurology - 1991

Multimedia gallery

Identified: the brain cell that regulates our decisions

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Publications

Latest publications

Injection of adult neurospheres induce clinical recovery in a chronic model of multiple sclerosis.

Nature 2003;422:688-694

Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani g, Dina G, Galli r, Bergami A, Furlan F, Delcarro U, Amadio S, Comi G, Vescovi AL, Martino G.

How the brain repairs itself: perspectives for new therapeutic strategies for inflammatory and degenerative CNS disorders.

Lancet Neurol. 2004;3:372-378

Martino G

Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism.

Nature 2005;436:266-271.

Pluchino S, Zanotti l, Rossi b, Brambilla e, Ottoboni l, Salani g, Martinello m, Cattalini A, Bergami A, Furlan R, Comi G, Constantin G, Martino G

The therapeutic potential of neural stem cells.

Nat. Rev. Neurosci. 2006;7:395-406.

Martino G, Pluchino S.

Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis.

J. Neurosci. 2009;29:3442-3452

Centone D*, Muzio L*, Rossi S, Cavasinni F, De Chiara V, Bergami A, Musella A, Marcello d’amelio M, Cavallucci V, Martorana A, Bergamaschi A, Concioni MT, Diamantini A, Butti E, Comi G, Bernardi G, Cecconi F, Battistini L, Furlan R, Martino G.

Delayed post-ischemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms.

Brain 2009;132:2239-2251

Bacigaluppi M*, Pluchino S*, Kilic E, Peruzzotti-Jametti L, Kilic U, Salani G, Brambilla E, Comi G, Martino G*, Hermann DM*.

Human neural stem cells ameliorate autoimmune encephalomyelitis in non human primates.

Ann. Neurol. 2009;66:343-354

Pluchino S*, Gritti A*, Blazer E, Amadio S, Brambilla E, Borsellino G, Cossetti C, Del Carro U, Comi G, ‘T Hart B, Vescovi A, Martino G

the Stem Cells in Multiple Sclerosis (STEMS) Consensus Group. Stem cell transplantation in multiple sclerosis: current status and future prospects.

Nat. Rev. Neurol. 2010;6:247-255.

Martino G, Franklin RJ, Van Evercooren AB, Kerr DA,

Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitoxicity.

Brain 2012;115:3320-3335.

Butti E, Bacigaluppi M, Rossi S, Cambiaghi M, Bari M, Cebrian Silla A, Brambilla E, Musella A, De Ceglia R, Teneud L, De Chiara V, D’adamo P, Garcia-Verdugo JM, Comi G, Muzio L, Quattrini A, Leocani L, Maccarrone M, Centonze D, Martino G.

Cross-talk between neural stem cells and immune cells: the key to better brain repair?

Nat. Neurosci. 2012;15:1078-1087

Kokaia Z*, Martino G*, Schwartz M*, Lindvall O

Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitoxicity.

Brain 2012;115:3320-3335

Butti E*, Bacigaluppi M*, Rossi S, Cambiaghi M, Bari M, Cebrian Silla A, Brambilla E, Musella A, De Ceglia R, Teneud L, De Chiara V, D’adamo P, Garcia-Verdugo JM, Comi G, Muzio L, Quattrini A, Leocani L, Maccarrone M, Centonze D, Martino G.

iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of leukemia inhibitory factor.

Nat. Commun. 2013;4:2597

Laterza C, Merlini A, De Feo D, Ruffini F, Menon R, Onorati M, Fredrickx E, Muzio L, Lombardo A, Comi G, Quattrini A, Taveggia C, Farina C, Cattaneo E, Martino G

Neural stem cell transplantation promotes post-ischemic neuronal plasticity by regulating the expression of glutamate transporters.

J. Neurosci. 2016;36:10529

Bacigaluppi M, Russo G*, Peruzzotti-Jametti L*, Rossi S, Sandrone S, Gallizioli M, De Ceglia R, Butti E, Studer V, Colombo E, Reitmeir R, Motta C, Muzio L, Comi G, Farina C, Letterio Politi LS, Invernizzi RW, Hermann DM*, Centonze D*, Martino G

Neural precursor cell-secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity.

J. Clin. Inv. 2017;127:3937-3953 Epub ahead of print on September 25, 2017

De Feo D, Merlini A, Brambilla E, Ottoboni L, Laterza C, Menon R, Srinivasan S, Farina C, Manteiga Jmg, Butti E, Bacigaluppi M, Comi G, Greter M, Martino G

Neural stem cells of the subventricular zone contribute to neuroprotection of the corpus callosum after cuprizone-induced demyelination.

J. Neurosci. 2019;39:5481-5492 [Epub ahead of print on May 28, 2019]

Butti E, Bacigaluppi M, Chaabane L, Ruffini F, Brambilla E, Berera G, Montonati C, Quattrini A, Martino G

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