Massimo Filippi

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Specialty:

Neurology Neurological and Functional Rehabilitation Rehabilitation

Profession:

Neurologist

Location:

Department of Neurology and Neurorehabilitation @ Ospedale San Raffaele

Languages:

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Biography

Professor Massimo Filippi is the Director of the Neurology Unit, the Neurophysiology Service, and the Neurorehabilitation Unit at IRCCS Ospedale San Raffaele. He is also responsible for the Functional Unit of the Bio-Signal Analysis Center and the current Director of the Quantitative Neuroimaging Research Unit of the Neuroscience Division at the same institute. He is a full professor of Neurology and the Director of the Neurology Residency School at Università Vita-Salute San Raffaele, where he is also the President of the Physiotherapy Degree Program, a member of the Academic Senate, and a member of the Steering Committee of the Interfaculty Center for Gender Studies.

He graduated in Medicine and Surgery in 1986 from the University of Milan, where he obtained his medical license. He then specialized in Neurology at the University of Milan (1990) and in Neurophysiopathology at the University of Pavia (1994). He began his academic career as a contract professor in the Neurology Residency School at the University of Chieti, in the Degree Program for Neurophysiopathology Technicians at the University of Milan, in the Faculty of Medicine and Surgery at Università Vita-Salute San Raffaele, and finally in the Neurology Residency School and the Degree Program in Physiotherapy at the same University.

He is a member of important scientific societies, such as the Italian Society of Clinical Neurophysiology, the Italian Society of Neurology, the European Neurological Society, the American Academy of Neurology, the International Society for Magnetic Resonance in Medicine, and the New York Academy of Sciences and the American Association for the Advancement of Science.

He is a member of the Editorial Board of numerous international scientific journals and regularly reviews in the fields of neurology and neuroimaging, also for government agencies and private foundations. He is the Editor-in-Chief of the Journal of Neurology and Associate Editor of the journals Radiology and Neurological Sciences. He has authored over 1000 peer-reviewed scientific publications, with a total H-index of 116 (Scopus), and 196 book chapters.

Education

University of Milan
Degree in Medicine and Surgery - 1986

University of Milan
Specialization in Neurology - 1990

University of Pavia
Specialization in Neuropathophysiology - 1994

Multimedia gallery

Demyelination disease: what is it?

Multiple sclerosis: what are the symptoms and available treatments?

EMA Approves Alzheimer's Drug for Early Treatment: Ospedale San Raffaele Has Started Administering It

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Publications

He is the member of the Editorial Board of numerous international scientific journals and regularly serves as a reviewer in neurology and neuroimaging, including for government agencies and private foundations. He is also the Editor-in-Chief of the Journal of Neurology and Associate Editor of Radiology and Neurological Sciences. He is the author of over 1000 peer-reviewed scientific publications with a total Hirsch index of 116 (Scopus), as well as 196 book chapters.

Latest publications

Interferon beta-1a for brain tissue loss in patients at presentation with syndromes suggestive of multiple sclerosis: a randomised, double-blind, placebo-controlled trial.

Lancet 2004; 364: 1489-1496

Filippi M, Rovaris M, Inglese M, Barkhof F, De Stefano N, Smith S, Comi G, and the ETOMS Study Group.

Effects of oral glatiramer acetate on clinical and MRI-monitored disease activity in patients with relapsing multiple sclerosis: a multicentre, double-blind, randomised, placebo-controlled study

Lancet Neurol 2006; 5: 213-220 [Epub ahead of print, 2006 January 20]

Filippi M, Wolinsky JS, Comi G and the CORAL Study Group

Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

Lancet 2008; 371: 2085-2092

Comi G, Pulizzi A, Rovaris M, Abramsky O, Arbizu T, Boiko A, Gold R, Havrdova E, Komoly S, Selmaj KW, Sharrack B, Filippi M for the LAQ/5062 Study Group

Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial.

Lancet 2009;374:1503-1511 [Epub ahead of print 7 October 2009; doi: 10.1016/S0140-6736(09)61259-9]

Comi G, Martinelli V, Rodegher M, Moiola L, Bajenaru O, Carra A, Elovaara I, Fazekas F, Hartung HP, Hillert J, King J, Komoly S, Lubetzki C, Montalban X, Myhr KM, Ravnborg M, Rieckmann P, Wynn D, Young C, Filippi M for the PreCISe study group

Assessment of brain system dysfunction through MRI-based connectomics.

Lancet Neurol 2013; 12: 1189-1199 [Epub ahead of print 11 October 2013; doi: 10.1016/S1474-4422(13)70144-3]

Filippi M, van den Heuvel MP, Fornito A, He Y, Hulshoff Pol HE, Agosta F, Comi G, Rocca MA

Progress towards a neuroimaging biomarker for amyotrophic lateral sclerosis.

Lancet Neurol 2015; 14: 786-788 [doi: 10.1016/S1474-4422(15)00134-9]

Filippi M, Agosta F, Grosskreutz J, Benatar M, Kassubek J, Verstraete E, Turner MR, on behalf of the Neuroimaging Society in ALS (NiSALS)

MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines.

Lancet Neurol 2016; 15: 292-303 [doi: 10.1016/S1474-4422(15)00393-

Filippi M, Rocca MA, Ciccarelli O, De Stefano N, Evangelou N, Kappos L, Rovira A, Sastre-Garriga J, Tintorè M, Frederiksen JL, Gasperini C, Palace J, Reich DS, Banwell B, Montalban X, Barkhof F, on behalf of the MAGNIMS Study Group.

Brain network connectivity differs in early-onset neurodegenerative dementia.

Neurology 2017; 89: 1764-1772 [epub ahead of print 27 September 2017; doi: 10.1212/WNL.0000000000004577]

Filippi M, Basaia S, Canu E, Imperiale F, Meani A, Caso F, Magnani G, Falautano M, Comi G, Falini A, Agosta F.

Long-term disability progression in primary progressive multiple sclerosis: a 15 year study.

Brain 2017; 140: 2814-2819 [epub ahead of print 27 September 2017; doi: 10.1093/brain/awx250]

Rocca MA, Sormani MP, Rovaris M, Caputo D, Ghezzi A, Montanari E, Bertolotto A, Laroni A, Bergamaschi R, Martinelli V, Comi G, Filippi M.

Brain structural and functional signatures of impulsive-compulsive behaviours in Parkinson's disease.

Mol Psychiatr 2018; 23: 459-466 [Epub ahead of print 7 March 2017; doi: 10.1038/mp.2017.18]

Imperiale F, Agosta F, Canu E, Markovic V, Inuggi A, Jecmenica-Lukic M, Tomic A, Copetti M, Basaia S, Kostic VS, Filippi M.

Prediction of a multiple sclerosis diagnosis in patients with clinically isolated syndrome using the 2016 MAGNIMS and 2010 McDonald criteria: a retrospective study

Lancet Neurol 2018; 17: 133-142 [epub ahead of print 21 December 2017; doi: 10.1016/S1474-4422(17)30469-6]

Filippi M, Preziosa P, Meani A, Ciccarelli O, Mesaros S, Rovira A, Frederiksen J, Enzinger C, Barkhof F, Gasperini C, Brownlee W, Drulovic J, Montalban X, Cramer SP, Pichler A, Hagens M, Ruggieri S, Martinelli V, Miszkiel K, Tintorè M, Comi G, Dekker I, Uitdehaag B, Dujmovic-Basuroski I, Rocca MA

Unraveling ALS due to SOD1 mutation through the combination of brain and cervical cord MRI.

Neurology 2018; 90: e707-e716 [epub ahead of print 24 January 2018; doi: 10.1212/WNL.0000000000005002]

Agosta F, Spinelli EG, Marjanovic IV, Stevic Z, Pagani E, Valsasina P, Salak-Djokic B, Jankovic M, Lavrnic D, Kostic VS, Filippi M.

Association between pathological and MRI findings in multiple sclerosis: an update.

Lancet Neurol 2019; 18: 198-210 [doi: 10.1016/S1474-4422(18)30451-4]

Filippi M, Brück W, Chard D, Fazekas F, Geurts JJG, Enzinger C, Hametner S, Kuhlmann T, Preziosa P, Rovira A, Schmierer K, Stadelmann C, Rocca MA, for the Attendees of the Correlation between Pathological and MRI findings in MS workshop.

Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines.

Brain 2019; 142: 1858-1975 [epub ahead of print 17 June 2019; doi: 10.1093/brain/awz144]

Filippi M, Preziosa P, Banwell BL, Barkhof F, Ciccarelli O, De Stefano N, Geurts JJG, Paul F, Reich DS, Toosy AT, Traboulsee A, Wattjes MP, Yousry TA, Gass A, Lubetzki C, Weinshenker BG, Rocca MA.

Changes in functional and structural brain connectome along the Alzheimer’s disease continuum.

Mol Psychiatr 2019 (in press) [epub ahead of print 9 May 2018; doi: 10.1038/s41380-018-0067-8]

Filippi M, Basaia S, Canu E, Imperiale F, Magnani G, Falautano M, Comi G, Falini A, Agosta F.